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KMID : 0388420000100010049
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Konkuk Journal of Medical Sciences
2000 Volume.10 No. 1 p.49 ~ p.57
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Echocardiographic Evaluation of the Effect of Beta Blocker on the Left Ventricular Failure
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Chung Sang-Man
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Abstract
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Background :
Methods : 19 patients of congestive heart failure under stable condition by conventional management were selected. From 12.5mg to 25mg of carvedilol was given according to the clinical condition. The blood pressure(BP), heart rate(HRLs left ventricular end diastolic dimension(LVEDD), left ventricular end systolic dimension(LVESD), ejection fraction(EF), mitral doppler E wave deceleration time(Ew DT), E/A ratio were measured by echocardiographic. examination before t, and 3 months after carvedilol trial.
Results : The HR and systolic BP were decreased from 88.423.8 to 69.719.32 (p<0.00001) and from 123.713.1mmHg to 113.426.9mmHg(p(0.05) respectively by carvedilol treatment. The LVED volume index was also decreased from 123.4 71.Om1/m2 to 98.760.9m1/m2(p<0.0001) by carvedilol. And the EF was increased from 42.817.4% to 53.016.7%(p(0.05) by carvedilol. The Ew DT after carvedilol trial was increased from 169.179.Omsee to 199.694.6msee(p<0.05). However the E/A ratio was not changed,
Conclusion : Carvedilol is a useful adjunctive therapy for congestive heart failure patients under conventional treatment by improving left ventricular systolic and diastolic function.
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KEYWORD
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beta blocker, congestive heart failure
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